SIKIK FUNDAMENTALS EXPLAINED

The functionality of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which plays a crucial regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also encourag